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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

Hypoferremia is a common response to systemic infections or generalized inflammatory disorders. In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin are la...

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Bibliografiske detaljer
Main Authors: Nemeth, Elizabeta, Rivera, Seth, Gabayan, Victoria, Keller, Charlotte, Taudorf, Sarah, Pedersen, Bente K., Ganz, Tomas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC398432/
https://ncbi.nlm.nih.gov/pubmed/15124018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420945
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