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The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G(2)/M checkpoint by facilitating CDC25A degradation
The p97-Ufd1-Npl4 ATPase complex is associated with the response to DNA damage and replication stress, but how its inactivation leads to manifestation of chromosome instability is unclear. Here, we show that p97-Ufd1-Npl4 has an additional direct role in the G(2)/M checkpoint. Upon DNA damage, p97-U...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Landes Bioscience
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3984315/ https://ncbi.nlm.nih.gov/pubmed/24429874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27779 |
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