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Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy

p97 is a key regulator of numerous cellular pathways and associates with ubiquitin-binding adaptors to remodel ubiquitin-modified substrate proteins. How adaptor binding to p97 is coordinated and how adaptors contribute to substrate remodeling is unclear. Here we present the 3D electron cryomicrosco...

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Bibliografische gegevens
Hoofdauteurs: Bebeacua, Cecilia, Förster, Andreas, McKeown, Ciarán, Meyer, Hemmo H., Zhang, Xiaodong, Freemont, Paul S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268311/
https://ncbi.nlm.nih.gov/pubmed/22232657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114341109
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