Mutation of Putative GRK Phosphorylation Sites in the Cannabinoid Receptor 1 (CB(1)R) Confers Resistance to Cannabinoid Tolerance and Hypersensitivity to Cannabinoids in Mice

For many G-protein-coupled receptors (GPCRs), including cannabinoid receptor 1 (CB(1)R), desensitization has been proposed as a principal mechanism driving initial tolerance to agonists. GPCR desensitization typically requires phosphorylation by a G-protein-coupled receptor kinase (GRK) and interact...

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Detalhes bibliográficos
Main Authors: Morgan, Daniel J., Davis, Brian J., Kearn, Chris S., Marcus, David, Cook, Alex J., Wager-Miller, Jim, Straiker, Alex, Myoga, Michael H., Karduck, Jeffrey, Leishman, Emma, Sim-Selley, Laura J., Czyzyk, Traci A., Bradshaw, Heather B., Selley, Dana E., Mackie, Ken
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983798/
https://ncbi.nlm.nih.gov/pubmed/24719095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3445-12.2014
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