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Functional Selectivity in CB(2) Cannabinoid Receptor Signaling and Regulation: Implications for the Therapeutic Potential of CB(2) Ligands
Receptor internalization increases the flexibility and scope of G protein-coupled receptor (GPCR) signaling. CB(1) and CB(2) cannabinoid receptors undergo internalization after sustained exposure to agonists. However, it is not known whether different agonists internalize CB(2) to different extents....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3263955/ https://ncbi.nlm.nih.gov/pubmed/22064678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.074013 |
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