A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.

The inducible, higher eukaryotic transcription factor NF-kappa B is activated by a variety of external stimuli including inflammatory cytokines, viral and bacterial infection and UV irradiation. Here we show that internal stress, caused by the accumulation of proteins in the endoplasmic reticulum (E...

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Bibliographic Details
Published in:EMBO J
Main Authors: Pahl, H L, Baeuerle, P A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC398372/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7781611/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb07256.x
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