Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

ZAP-70 is a protein tyrosine kinase (PTK) required for T-cell development and T-cell antigen receptor (TCR) function. ZAP-70 is associated with the phosphorylated antigen receptor and undergoes tyrosine phosphorylation following receptor activation. We demonstrate here that tyrosine phosphorylation...

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Bibliographic Details
Main Authors: Chan, A C, Dalton, M, Johnson, R, Kong, G H, Wang, T, Thoma, R, Kurosaki, T
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC398363/
https://ncbi.nlm.nih.gov/pubmed/7781602
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