Synapto-depressive effects of amyloid beta require PICK1

Amyloid beta (Aβ), a key component in the pathophysiology of Alzheimer’s disease, is thought to target excitatory synapses early in the disease. However, the mechanism by which Aβ weakens synapses is not well understood. Here we showed that the PDZ domain protein, protein interacting with C kinase 1...

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Detalhes bibliográficos
Main Authors: Alfonso, Stephanie, Kessels, Helmut W., Banos, Charles C., Chan, Timothy R., Lin, Edward T., Kumaravel, Gnanasambandam, Scannevin, Robert H., Rhodes, Kenneth J., Huganir, Richard, Guckian, Kevin M., Dunah, Anthone W., Malinow, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983572/
https://ncbi.nlm.nih.gov/pubmed/24713001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.12499
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