PSD-95 protects synapses from β-amyloid

Beta-amyloid (Aβ) depresses excitatory synapses by a poorly understood mechanism requiring NMDA receptor (NMDAR) function. Here, we show that increased PSD-95, a major synaptic scaffolding molecule, blocks the effects of Aβ on synapses. The protective effect persists in tissue lacking the AMPA recep...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Dore, Kim, Carrico, Zachary, Alfonso, Stephanie, Marino, Marc, Koymans, Karin, Kessels, Helmut W., Malinow, Roberto
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8237704/
https://ncbi.nlm.nih.gov/pubmed/34077732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109194
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