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Structural Modifications of Neuroprotective Anti-Parkinsonian (−)-N6-(2-(4-(Biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): An Effort toward the Improvement of in Vivo Efficacy of the Parent Molecule
[Image: see text] In our overall goal to develop multifunctional dopamine D(2)/D(3) agonist drugs for the treatment of Parkinson’s disease (PD), we previously synthesized potent D(3) preferring agonist D-264 (1a), which exhibited neuroprotective properties in two animal models of PD. To enhance the...
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Hlavní autoři: | , , , |
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Médium: | Artigo |
Jazyk: | Inglês |
Vydáno: |
American Chemical
Society
2014
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On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3983390/ https://ncbi.nlm.nih.gov/pubmed/24471976 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401883v |
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