Coarse Grained Models Reveal Essential Contributions of Topological Constraints to the Conformational Free Energy of RNA Bulges

[Image: see text] Recent studies have shown that simple stereochemical constraints encoded at the RNA secondary structure level significantly restrict the orientation of RNA helices across two-way junctions and yield physically reasonable distributions of RNA 3D conformations. Here we develop a new...

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Hlavní autoři: Mustoe, Anthony M., Al-Hashimi, Hashim M., Brooks, Charles L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983386/
https://ncbi.nlm.nih.gov/pubmed/24547945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp411478x
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