Post-Translational Decrease in Respiratory Chain Proteins in the Polg Mutator Mouse Brain

Mitochondrial DNA damage is thought to be a causal contributor to aging as mice with inactivating mutations in polymerase gamma (Polg) develop a progeroid phenotype. To further understand the molecular mechanisms underlying this phenotype, we used iTRAQ and RNA-Seq to determine differences in protei...

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Bibliographic Details
Main Authors: Hauser, David N., Dillman, Allissa A., Ding, Jinhui, Li, Yan, Cookson, Mark R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983222/
https://ncbi.nlm.nih.gov/pubmed/24722488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094646
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