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Post-Translational Decrease in Respiratory Chain Proteins in the Polg Mutator Mouse Brain
Mitochondrial DNA damage is thought to be a causal contributor to aging as mice with inactivating mutations in polymerase gamma (Polg) develop a progeroid phenotype. To further understand the molecular mechanisms underlying this phenotype, we used iTRAQ and RNA-Seq to determine differences in protei...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3983222/ https://ncbi.nlm.nih.gov/pubmed/24722488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094646 |
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