A Quantitative High-Resolution Genetic Profile Rapidly Identifies Sequence Determinants of Hepatitis C Viral Fitness and Drug Sensitivity

Widely used chemical genetic screens have greatly facilitated the identification of many antiviral agents. However, the regions of interaction and inhibitory mechanisms of many therapeutic candidates have yet to be elucidated. Previous chemical screens identified Daclatasvir (BMS-790052) as a potent...

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Detalhes bibliográficos
Main Authors: Qi, Hangfei, Olson, C. Anders, Wu, Nicholas C., Ke, Ruian, Loverdo, Claude, Chu, Virginia, Truong, Shawna, Remenyi, Roland, Chen, Zugen, Du, Yushen, Su, Sheng-Yao, Al-Mawsawi, Laith Q., Wu, Ting-Ting, Chen, Shu-Hua, Lin, Chung-Yen, Zhong, Weidong, Lloyd-Smith, James O., Sun, Ren
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983061/
https://ncbi.nlm.nih.gov/pubmed/24722365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004064
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