Crystal structure of the trithorax group protein Ash2L reveals a Forkhead-like DNA binding domain

Human ASH2L is a trithorax group (TrxG) protein and a regulatory subunit of the SET1 family of lysine methyltransferases. Here we report that Ash2L binds DNA employing a Forkhead-like helix-wing-helix (HWH) domain. In vivo, Ash2L HWH domain is required for binding to the β-globin locus control regio...

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Hauptverfasser: Sarvan, Sabina, Avdic, Vanja, Tremblay, Véronique, Chaturvedi, Chandra-Prakash, Zhang, Pamela, Lanouette, Sylvain, Blais, Alexandre, Brunzelle, Joseph S., Brand, Marjorie, Couture, Jean-François
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983046/
https://ncbi.nlm.nih.gov/pubmed/21642971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2093
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