Effects of Calibration Approaches on the Accuracy for LC–MS Targeted Quantification of Therapeutic Protein

[Image: see text] LC–MS provides a promising alternative to ligand-binding assays for quantification of therapeutic proteins and biomarkers. As LC–MS methodology is based on the analysis of proteolytic peptides, calibration approaches utilizing various calibrators and internal standards (I.S.) have...

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Detalhes bibliográficos
Main Authors: Nouri-Nigjeh, Eslam, Zhang, Ming, Ji, Tao, Yu, Haoying, An, Bo, Duan, Xiaotao, Balthasar, Joseph, Johnson, Robert W., Qu, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982980/
https://ncbi.nlm.nih.gov/pubmed/24611550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac5001477
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