Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors

The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But mTOR is not an oncogene, and which tumors will be resistant or sensitive to new ATP-competitive mTOR inhibitors now in clinical trials remains...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ducker, Gregory S., Atreya, Chloe E., Simko, Jeffry P., Hom, Yun K., Matli, Mary R., Benes, Cyril H., Hann, Byron, Nakakura, Eric K., Bergsland, Emily K., Donner, David B., Settleman, Jeffrey, Shokat, Kevan M., Warren, Robert S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982880/
https://ncbi.nlm.nih.gov/pubmed/23542178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.92
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