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HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells

HIV associated nephropathy (HIVAN) is a major cause of HIV related morbidity and mortality. Pathogenesis involves direct infection of the glomerular and tubular epithelial cells leading to characteristic pathology. Recently, we have shown that HIV-1 Vpr causes hypertrophy, hyperploidy, and apoptosis...

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Detalhes bibliográficos
Main Authors: Rosenstiel, Paul E., Chan, Justin, Snyder, Alexander, Planelles, Vicente P., D’Agati, Vivette D., Klotman, Paul E., Klotman, Mary E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982604/
https://ncbi.nlm.nih.gov/pubmed/19657269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e32833088a0
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