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Cysteine protease inhibition by nitrile-based inhibitors: a computational study
Cysteine protease enzymes are important for human physiology and catalyze key protein degradation pathways. These enzymes react via a nucleophilic reaction mechanism that involves a cysteine residue and the proton of a proximal histidine. Particularly efficient inhibitors of these enzymes are nitril...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3982517/ https://ncbi.nlm.nih.gov/pubmed/24790966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2013.00039 |
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