Alphavirus-based Vaccines Encoding Nonstructural Proteins of Hepatitis C Virus Induce Robust and Protective T-cell Responses

An absolute prerequisite for a therapeutic vaccine against hepatitis C virus (HCV) infection is the potency to induce HCV-specific vigorous and broad-spectrum T-cell responses. Here, we generated three HCV vaccines based on a recombinant Semliki Forest virus (rSFV) vector expressing all- or a part o...

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Detalhes bibliográficos
Main Authors: Ip, Peng Peng, Boerma, Annemarie, Regts, Joke, Meijerhof, Tjarko, Wilschut, Jan, Nijman, Hans W, Daemen, Toos
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982487/
https://ncbi.nlm.nih.gov/pubmed/24370701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.287
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