A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 is highly responsive to mTOR inhibition

Signals from the tumor suppressors PTEN and LKB1 converge on mTOR to negatively regulate its function in cancer cells. Notably, both of these suppressors are attenuated in a significant fraction of human endometrial tumors. In this study, we generated a genetic mouse model of endometrial cancer driv...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Cheng, Hailing, Liu, Pixu, Zhang, Fan, Xu, Erbo, Symonds, Lynn, Ohlson, Carolynn E., Bronson, Roderick T., Maira, Sauveur-Michel, Tomaso, Emmanuelle Di, Li, Jane, Myers, Andrea P., C.Cantley, Lewis, Mills, Gordon B., Zhao, Jean J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982380/
https://ncbi.nlm.nih.gov/pubmed/24322983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0544
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