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Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis
The E3 ubiquitin ligase Parkin plays a central role in the pathogenesis of many neurodegenerative diseases. Parkin promotes specific ubiquitination and affects the localization of TDP-43, which controls the translation of thousands of mRNAs. Here we tested the effects of lentiviral Parkin and TDP-43...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3982293/ https://ncbi.nlm.nih.gov/pubmed/24298989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.12630 |
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