Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1

Intracellular microRNAs (miRNAs) are key regulators of gene expression. The role of extracellular miRNAs in neuronal activation and sensory behaviors are unknown. Here we report an unconventional role of extracellular miRNAs for rapid excitation of nociceptor neurons via toll-like receptor-7 (TLR7)...

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Autors principals: Park, Chul-Kyu, Xu, Zhen-Zhong, Berta, Temugin, Han, Qingjian, Chen, Gang, Liu, Xing-Jun, Ji, Ru-Rong
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982230/
https://ncbi.nlm.nih.gov/pubmed/24698267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.02.011
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