Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion

Increasing evidence indicates that the pathogenesis of neuropathic pain is mediated through spinal cord microglia activation. The intracellular protease caspase-6 (CASP6) is known to regulate neuronal apoptosis and axonal degeneration; however, the contribution of microglia and CASP6 in modulating s...

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Bibliografski detalji
Glavni autori: Berta, Temugin, Park, Chul-Kyu, Xu, Zhen-Zhong, Xie, Ruo-Gang, Liu, Tong, Lü, Ning, Liu, Yen-Chin, Ji, Ru-Rong
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2014
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934175/
https://ncbi.nlm.nih.gov/pubmed/24531553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72230
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