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Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion
Increasing evidence indicates that the pathogenesis of neuropathic pain is mediated through spinal cord microglia activation. The intracellular protease caspase-6 (CASP6) is known to regulate neuronal apoptosis and axonal degeneration; however, the contribution of microglia and CASP6 in modulating s...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3934175/ https://ncbi.nlm.nih.gov/pubmed/24531553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72230 |
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