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Pyroptotic neuronal cell death mediated by the AIM2 inflammasome

The central nervous system (CNS) is an active participant in the innate immune response to infection and injury. In these studies, we show embryonic cortical neurons express a functional, deoxyribonucleic acid (DNA)-responsive, absent in melanoma 2 (AIM2) inflammasome that activates caspase-1. Neuro...

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Main Authors: Adamczak, Stephanie E, de Rivero Vaccari, Juan Pablo, Dale, Gordon, Brand, Frank J, Nonner, Doris, Bullock, MRoss, Dahl, Gerhard P, Dietrich, W Dalton, Keane, Robert W
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3982080/
https://ncbi.nlm.nih.gov/pubmed/24398937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2013.236
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