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OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange
The chemical nature and functional significance of mitochondrial flashes associated with fluctuations in mitochondrial membrane potential is unclear. Using a ratiometric pH probe insensitive to superoxide, we show that flashes reflect matrix alkalinization transients of ∼0.4 pH units that persist in...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
European Molecular Biology Organization
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3981180/ https://ncbi.nlm.nih.gov/pubmed/23714779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.124 |
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