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OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange

The chemical nature and functional significance of mitochondrial flashes associated with fluctuations in mitochondrial membrane potential is unclear. Using a ratiometric pH probe insensitive to superoxide, we show that flashes reflect matrix alkalinization transients of ∼0.4 pH units that persist in...

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Detalhes bibliográficos
Main Authors: Santo-Domingo, Jaime, Giacomello, Marta, Poburko, Damon, Scorrano, Luca, Demaurex, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981180/
https://ncbi.nlm.nih.gov/pubmed/23714779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.124
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