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OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange
The chemical nature and functional significance of mitochondrial flashes associated with fluctuations in mitochondrial membrane potential is unclear. Using a ratiometric pH probe insensitive to superoxide, we show that flashes reflect matrix alkalinization transients of ∼0.4 pH units that persist in...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
European Molecular Biology Organization
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3981180/ https://ncbi.nlm.nih.gov/pubmed/23714779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.124 |
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