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Loss of iron triggers PINK1/Parkin-independent mitophagy
In this study, we develop a simple assay to identify mitophagy inducers on the basis of the use of fluorescently tagged mitochondria that undergo a colour change on lysosomal delivery. Using this assay, we identify iron chelators as a family of compounds that generate a strong mitophagy response. Ir...
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| Main Authors: | , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
European Molecular Biology Organization
2013
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3981094/ https://ncbi.nlm.nih.gov/pubmed/24176932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.168 |
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