An acute myeloid leukemia gene, AML1, regulates hemopoietic myeloid cell differentiation and transcriptional activation antagonistically by two alternative spliced forms.

The AML1 gene on chromosome 21 is disrupted in the (8;21)(q22;q22) and (3;21)(q26;q22) translocations associated with myelogenous leukemias and encodes a DNA binding protein. From the AML1 gene, two representative forms of proteins, AML1a and AML1b, are produced by alternative splicing. Both forms h...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Tanaka, T, Tanaka, K, Ogawa, S, Kurokawa, M, Mitani, K, Nishida, J, Shibata, Y, Yazaki, Y, Hirai, H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC398088/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7530657/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb07008.x
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