Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells

Myeloid derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) represent prominent components in cancer progression. We previously showed that inhibition of the VEGFR-3 pathway by SAR131675 leads to reduction of TAM infiltration and tumor growth. Here, we found that treatment with...

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Main Authors: Espagnolle, Nicolas, Barron, Pauline, Mandron, Marie, Blanc, Isabelle, Bonnin, Jacques, Agnel, Magali, Kerbelec, Erwan, Herault, Jean Pascal, Savi, Pierre, Bono, Françoise, Alam, Antoine
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980599/
https://ncbi.nlm.nih.gov/pubmed/24589997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers6010472
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