Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of MnSOD via the SIRT1/FoxO3a Pathway

BACKGROUND: For reasons that remain unclear, whether type 5 AC (AC5), one of two major AC isoforms in heart, is protective or deleterious in response to cardiac stress is controversial. To reconcile this controversy we examined the cardiomyopathy induced by chronic isoproterenol (ISO) in AC5 transge...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Lai, Lo, Yan, Lin, Gao, Shumin, Hu, Che-Lin, Ge, Hui, Davidow, Amy, Park, Misun, Bravo, Claudio, Iwatsubo, Kousaku, Ishikawa, Yoshihiro, Auwerx, Johan, Sinclair, David A., Vatner, Stephen F., Vatner, Dorothy E.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980473/
https://ncbi.nlm.nih.gov/pubmed/23536361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.001212
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker