Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of MnSOD via the SIRT1/FoxO3a Pathway

BACKGROUND: For reasons that remain unclear, whether type 5 AC (AC5), one of two major AC isoforms in heart, is protective or deleterious in response to cardiac stress is controversial. To reconcile this controversy we examined the cardiomyopathy induced by chronic isoproterenol (ISO) in AC5 transge...

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Bibliografski detalji
Glavni autori: Lai, Lo, Yan, Lin, Gao, Shumin, Hu, Che-Lin, Ge, Hui, Davidow, Amy, Park, Misun, Bravo, Claudio, Iwatsubo, Kousaku, Ishikawa, Yoshihiro, Auwerx, Johan, Sinclair, David A., Vatner, Stephen F., Vatner, Dorothy E.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3980473/
https://ncbi.nlm.nih.gov/pubmed/23536361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.001212
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