Pharmacokinetics and Pharmacodynamics of ASKP1240, a Fully Human Anti-CD40 Antibody, in Normal and Renal Transplanted Cynomolgus Monkeys

BACKGROUND: The purpose of this study was to evaluate the serum concentration of ASKP1240 (pharmacokinetics [PK]) and the CD40 occupancy of ASKP1240 (pharmacodynamics [PD]) in normal and renal transplanted Cynomolgus monkeys to clarify the PK/PD relationship. METHODS: In a 70-day study, two ASKP1240...

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Detalhes bibliográficos
Main Authors: Ma, Anlun, Dun, Hao, Song, Lijun, Hu, Yanxin, Zeng, Lin, Bai, Jieying, Zhang, Guangzhou, Kinugasa, Fumitaka, Miyao, Yasuhiro, Sakuma, Shozo, Okimura, Kazumichi, Kasai, Noriyuki, Daloze, Pierre, Chen, Huifang
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2014
Assuntos:
Basic and Experimental Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979827/
https://ncbi.nlm.nih.gov/pubmed/24389907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.TP.0000440951.29757.bd
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