Characterization of ASKP1240, a Fully Human Antibody Targeting Human CD40 With Potent Immunosuppressive Effects

Blocking the CD40–CD154 interaction is reported to be effective for transplantation management and autoimmune disease models in rodents and nonhuman primates. However, clinical trials with anti-CD154 mAbs were halted because of high incidence of thromboembolic complications. Thus, we generated and c...

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Detalhes bibliográficos
Publicado no:Am J Transplant
Main Authors: Okimura, K, Maeta, K, Kobayashi, N, Goto, M, Kano, N, Ishihara, T, Ishikawa, T, Tsumura, H, Ueno, A, Miyao, Y, Sakuma, S, Kinugasa, F, Takahashi, N, Miura, T
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225473/
https://ncbi.nlm.nih.gov/pubmed/24731050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.12678
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