Characterization of ASKP1240, a Fully Human Antibody Targeting Human CD40 With Potent Immunosuppressive Effects

Blocking the CD40–CD154 interaction is reported to be effective for transplantation management and autoimmune disease models in rodents and nonhuman primates. However, clinical trials with anti-CD154 mAbs were halted because of high incidence of thromboembolic complications. Thus, we generated and c...

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Bibliografiske detaljer
Udgivet i:Am J Transplant
Main Authors: Okimura, K, Maeta, K, Kobayashi, N, Goto, M, Kano, N, Ishihara, T, Ishikawa, T, Tsumura, H, Ueno, A, Miyao, Y, Sakuma, S, Kinugasa, F, Takahashi, N, Miura, T
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225473/
https://ncbi.nlm.nih.gov/pubmed/24731050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ajt.12678
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