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Pharmacodynamic Model of Hepcidin Regulation of Iron Homeostasis in Cynomolgus Monkeys
Hepcidin (H(25)) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export. In this study, H(25) was inhibited by administration of single and multiple doses of an anti-H(25) monoclonal antibody Ab 12B9m in cynomolgus monkeys. The objective of this analysis was t...
Gorde:
| Argitaratua izan da: | AAPS J |
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| Egile Nagusiak: | , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Springer US
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5256605/ https://ncbi.nlm.nih.gov/pubmed/26917226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-016-9886-1 |
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