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Pharmacodynamic Model of Hepcidin Regulation of Iron Homeostasis in Cynomolgus Monkeys

Hepcidin (H(25)) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export. In this study, H(25) was inhibited by administration of single and multiple doses of an anti-H(25) monoclonal antibody Ab 12B9m in cynomolgus monkeys. The objective of this analysis was t...

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Bibliografski detalji
Izdano u:AAPS J
Glavni autori: Krzyzanski, Wojciech, Xiao, Jim J., Sasu, Barbra, Hinkle, Beth, Perez-Ruixo, Juan Jose
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256605/
https://ncbi.nlm.nih.gov/pubmed/26917226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-016-9886-1
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