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Trisubstituted Sulfonamides: A New Chemotype for Development of Potent and Selective CB(2) Receptor Inverse Agonists
[Image: see text] An extensive exploration of the structure–activity relationship of a trisubstituted sulfonamide series led to the identification of 39, which is a potent and selective CB(2) receptor inverse agonist [K(i)(CB(2)) = 5.4 nM, and K(i)(CB(1)) = 500 nM]. The functional properties measure...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3979583/ https://ncbi.nlm.nih.gov/pubmed/24729834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3004236 |
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