Lead Discovery, Chemistry Optimization, and Biological Evaluation Studies of Novel Biamide Derivatives as CB(2) Receptor Inverse Agonists and Osteoclast Inhibitors

[Image: see text] N,N′-((4-(Dimethylamino)phenyl)methylene)bis(2-phenylacetamide) was discovered by using 3D pharmacophore database searches and was biologically confirmed as a new class of CB(2) inverse agonists. Subsequently, 52 derivatives were designed and synthesized through lead chemistry opti...

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Detalhes bibliográficos
Main Authors: Yang, Peng, Myint, Kyaw-Zeyar, Tong, Qin, Feng, Rentian, Cao, Haiping, Almehizia, Abdulrahman A., Alqarni, Mohammed Hamed, Wang, Lirong, Bartlow, Patrick, Gao, Yingdai, Gertsch, Jürg, Teramachi, Jumpei, Kurihara, Noriyoshi, Roodman, Garson David, Cheng, Tao, Xie, Xiang-Qun
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967745/
https://ncbi.nlm.nih.gov/pubmed/23072339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301212u
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