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Trisubstituted Sulfonamides: A New Chemotype for Development of Potent and Selective CB(2) Receptor Inverse Agonists

[Image: see text] An extensive exploration of the structure–activity relationship of a trisubstituted sulfonamide series led to the identification of 39, which is a potent and selective CB(2) receptor inverse agonist [K(i)(CB(2)) = 5.4 nM, and K(i)(CB(1)) = 500 nM]. The functional properties measure...

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Autors principals: Ouyang, Qin, Tong, Qin, Feng, Rentian, Myint, Kyaw-Zeyar, Yang, Peng, Xie, Xiang-Qun
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979583/
https://ncbi.nlm.nih.gov/pubmed/24729834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3004236
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