VISTA is an immune checkpoint molecule for human T cells

VISTA is a potent negative regulator of T cell function that is expressed on hematopoietic cells and leukocytes. VISTA levels are heightened within the tumor microenvironment where its blockade can enhance anti-tumor immune responses in mice. In humans, blockade of the related PD-1 pathway has shown...

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Autori principali: Lines, J. Louise, Sempere, Lorenzo F., Wang, Li, Pantazi, Eirini, Mak, Justin, O’Connell, Samuel, Ceeraz, Sabrina, Suriawinata, Arief A., Yan, Shaofeng, Ernstoff, Marc S., Noelle, Randolph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979527/
https://ncbi.nlm.nih.gov/pubmed/24691993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1504
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