c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer

Metastasis suppressors comprise a growing class of genes whose downregulation triggers metastatic progression. In contrast to tumor suppressors, metastasis suppressors are rarely mutated or deleted, and little is known regarding the mechanisms by which their expression is downregulated. Here, we dem...

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Detalhes bibliográficos
Main Authors: Fiore, Leann S., Ganguly, Sourik S., Sledziona, James, Cibull, Michael L., Wang, Chi, Richards, Dana L., Neltner, Janna M., Beach, Carol, McCorkle, Joseph R., Kaetzel, David M., Plattner, Rina
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979510/
https://ncbi.nlm.nih.gov/pubmed/24096484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.399
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