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Hot spots in apolipoprotein A-II misfolding and amyloidosis in mice and men
ApoA-II is the second-major protein of high-density lipoproteins. C-terminal extension in human apoA-II or point substitutions in murine apoA-II cause amyloidosis. The molecular mechanism of apolipoprotein misfolding, from the native predominantly α-helical conformation to cross-β-sheet in amyloid,...
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3979420/ https://ncbi.nlm.nih.gov/pubmed/24561203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2014.01.066 |
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