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Structural and Computational Studies of the Staphylococcus aureus Sortase B-Substrate Complex Reveal a Substrate-stabilized Oxyanion Hole

Sortase cysteine transpeptidases covalently attach proteins to the bacterial cell wall or assemble fiber-like pili that promote bacterial adhesion. Members of this enzyme superfamily are widely distributed in Gram-positive bacteria that frequently utilize multiple sortases to elaborate their peptido...

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Detalhes bibliográficos
Main Authors: Jacobitz, Alex W., Wereszczynski, Jeff, Yi, Sung Wook, Amer, Brendan R., Huang, Grace L., Nguyen, Angelyn V., Sawaya, Michael R., Jung, Michael E., McCammon, J. Andrew, Clubb, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979406/
https://ncbi.nlm.nih.gov/pubmed/24519933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.509273
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