Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein D upon binding to HVEM and nectin-1

Herpes simplex virus entry is initiated by glycoprotein D (gD) binding to a cellular receptor, such as HVEM or nectin-1. gD is activated by receptor-induced displacement of the C-terminus from the core of the glycoprotein. Binding of HVEM requires the formation of an N-terminal hairpin loop of gD; o...

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Main Authors: Lazear, Eric, Whitbeck, J. Charles, Zuo, Yi, Carfí, Andrea, Cohen, Gary H., Eisenberg, Roselyn J., Krummenacher, Claude
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979344/
https://ncbi.nlm.nih.gov/pubmed/24314649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.10.019
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