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An efficient and practical radiosynthesis of [(11)C]temozolomide

[Image: see text] Temozolomide (TMZ) is a prodrug for an alkylating agent used for the treatment of malignant brain tumors. A positron emitting version, [(11)C]TMZ, has been utilized to help elucidate the mechanism and biodistribution of TMZ. Challenges in [(11)C]TMZ synthesis and reformulation make...

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Autors principals: Moseley, Christian K., Carlin, Stephen M., Neelamegam, Ramesh, Hooker, Jacob M.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979304/
https://ncbi.nlm.nih.gov/pubmed/23151019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol302791x
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