Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-κB inhibition

INTRODUCTION: Detyrosinated tubulin, a post-translational modification of α-tubulin and a hallmark of stable microtubules, has gained recent attention given its association with tumor progression, invasiveness, and chemoresistance. We also recently reported that epithelial-to-mesenchymal transition...

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Hauptverfasser: Whipple, Rebecca A, Vitolo, Michele I, Boggs, Amanda E, Charpentier, Monica S, Thompson, Keyata, Martin, Stuart S
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979133/
https://ncbi.nlm.nih.gov/pubmed/24028602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3477
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