Cytokine signaling-1 suppressor is inducible by IL-1beta and inhibits the catabolic effects of IL-1beta in chondrocytes: its implication in the paradoxical joint-protective role of IL-1beta

INTRODUCTION: Although IL-1β is believed to be crucial in the pathogenesis of osteoarthritis (OA), the IL-1β blockade brings no therapeutic benefit in human OA and results in OA aggravation in several animal models. We explored the role of a cytokine signaling 1 (SOCS1) suppressor as a regulatory mo...

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Main Authors: Choi, Yong Seok, Park, Jin Kyun, Kang, Eun Ha, Lee, Young-Kyun, Kim, Tae Kyun, Chung, Jin-Haeng, Zimmerer, Jason M, Carson, William E, Song, Yeong Wook, Lee, Yun Jong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979110/
https://ncbi.nlm.nih.gov/pubmed/24238405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4381
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