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Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection

The combination of an E2 ubiquitin-conjugating enzyme with an E3 ubiquitin-ligase is essential for ubiquitin modification of a substrate. Moreover, the pairing dictates both the substrate choice and the modification type. The molecular details of generic E3-E2 interactions are well established. Neve...

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Main Authors: Hodson, Charlotte, Purkiss, Andrew, Miles, Jennifer Anne, Walden, Helen
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979106/
https://ncbi.nlm.nih.gov/pubmed/24389026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.12.004
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