Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes

INTRODUCTION: AMP-activated protein kinase (AMPK) maintains cultured chondrocyte matrix homeostasis in response to inflammatory cytokines. AMPK activity is decreased in human knee osteoarthritis (OA) chondrocytes. Liver kinase B1 (LKB1) is one of the upstream activators of AMPK. Hence, we examined t...

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Bibliographic Details
Main Authors: Petursson, Freyr, Husa, Matt, June, Ron, Lotz, Martin, Terkeltaub, Robert, Liu-Bryan, Ru
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979085/
https://ncbi.nlm.nih.gov/pubmed/23883619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4254
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