Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation

INTRODUCTION: Estrogen receptor α-positive (ER+) breast cancers adapt to hormone deprivation and acquire resistance to antiestrogen therapies. Upon acquisition of hormone independence, ER+ breast cancer cells increase their dependence on the phosphatidylinositol-3 kinase (PI3K)/AKT pathway. We exami...

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Hlavní autoři: Fox, Emily M, Kuba, María Gabriela, Miller, Todd W, Davies, Barry R, Arteaga, Carlos L
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3979036/
https://ncbi.nlm.nih.gov/pubmed/23844554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3449
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